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Prosjekttilbud - Forskerlinjen - Medisinstudiet

Her legges det ut prosjekttilbud som er særskilt meldt inn av veiledere. Få ideer til forskningsprosjekter og tematiske forskningsområder ved å se på  instituttenes web-sider, oversikt over instituttgrupper og forskergrupper. Ta gjerne direkte kontakt med gruppenes kontaktpersoner for mer informasjon. 

Respiratory virus in children with airway infections #

Background: Children have on average six respiratory tract infections (RTI) each year. The majority are mild infections in upper airways, but some may involve lower airways, leading to more severe manifestations and need of hospitalization. In well-vaccinated children, the rate of bacterial RTIs have decreased, whereas the causative impact of viruses is likely to have increased. Recent years, new airway viruses have been detected. As an example, human metapneumonivirus was detected in 2002. We have previous ly studied the incidence and clinical manifestations of this virus among children hospitalized at St. Olavs hospital.

Aim: We aim to describe the burden of human metapneumovirus lower airway infections in children in Norway.

Methods: We will use a dataset from the NOREPIS study comprising nearly 3000 children enrolled from November 2015 to May 2018 at five Norwegian hospitals due to cough, fever, and other signs of respiratory infections. These 5 hospitals care for approximately 40% of Norwegian children. Parents to all children contended to participation. We include children < 5 years old among who 243 had HMPV, and 1090 had RSV. All children were sampled with a nasopharyngeal swap. Swaps were analyzed at each hospital laboratories using various polymerase chain reaction (PCR) test methods. Clinical information was collected.

The task is 1) to re-test all HMPV positive samples and a random selected group of comparable number with RSV, using in-house TaqMan real-time PCR assays, and to genotype HMPV-positive specimens by real-time PCR and DNA sequencing using primers targeting the F-gene of HMPV. 2) to calculate incidence rates of human metapneumovirus lower airway infections in children < 5 years old, and 3) describe clinical manifestations, risk factors and outcome compared to RSV.

Research student thesis: The dataset may be used to write 3 papers.

Research group and mentors: The study is a part of the studies in the CAIR-group. Mentors will be associate professor Andreas Christensen and professor Henrik Døllner, IKOM.

Kognitiv svikt etter hjerneslag #

Årlig rammes ca. 12.000 personer i Norge av hjerneslag, og antallet personer som lever med ettervirkningene av hjerneslag er høyt og økende. Omtrent 10% får demens som følge av et førstegangshjerneslag og 30% av de som har hatt hjerneslag flere ganger. I tillegg til de som får demens, er det også mange som får mild kognitiv svikt. Demens og kognitiv svikt etter hjerneslag er en stor belastning både for den enkelte pasient, pårørende og samfunnet.

I perioden 2015-2020 gjennomføres en stor oppfølgingsstudie av pasienter med hjerneslag som ble innlagt ved fem norske sykehus, The Norwegian Cognitive Impairment After Stroke study (NorCOAST). Studien har inkludert 815 pasienter og er i 2020 ferdig med å følge opp pasientene i tre år etter hjerneslaget. Studien kartlegger kognitiv svikt etter hjerneslag for å gi svar på hvor vanlig det er, hvilke kognitive domener som rammes, hvordan den kognitive funksjonen endres over tid og hvilke faktorer som påvirker kognisjon etter hjerneslag.

NorCOAST-studien har etablert et nasjonalt forskernettverk for kognitiv svikt etter hjerneslag og det er mange pågående forskningsprosjekter tilknyttet studien, både ph.d.-prosjekter, postdoktorprosjekter, masteroppgaver, hovedoppgaver og en forskerlinjeoppgave. Aktuelle prosjekter for en forskerlinjestudent kan være å se på

  • svikt i spesifikke kognitive evner (rom-retningssans, eventuelt språk)
  • hvordan genetiske forhold innvirker på kognitiv svikt etter hjerneslag
  • sammenhengen mellom hvordan pasienten selv opplever sin situasjon etter hjerneslaget og hvilken svikt kognitive tester viser

Studien er svært interessert i videre samarbeid med forskerlinjestudenter og vi ber om at interesserte studenter kontakter oss snarest for en uforpliktende prat.

Kontaktpersoner: Ingvild Saltvedt ingvild.saltvedt@ntnu.no og Rannveig Eldholm rannveig.s.eldholm@ntnu.no, begge Institutt for Nevromedisin og bevegelsesvitenskap og Avdeling for geriatri, St.Olavs hospital 

Sleep better to feel better #

Sleep is a fundamental human need with large impact on both psychological and somatic health. However, for patients with mental disorders, sleep is often disturbed. Across all diagnostic groups, sleep disturbance is one of the most common and disruptive symptoms. For decades, it has been assumed that the sleep disturbance these patients experience was a secondary symptom of a primary mental disorder, but recently this has changed. Experimental and clinical data now suggest that there is a reciprocal relationship between sleep disturbance and mental disorders where they perpetuate and aggravate each other. This makes sleep disturbance a potential therapeutic target in the treatment of mental disorders.

Evidence emerging the last decade indicate that providing Cognitive Behavior Therapy for Insomnia (CBT-I) to patients with mental disorders not only improves sleep, but also has clinically meaningful effects on their primary mental disorder. However, a major problem has been disseminating CBT-I and few therapists are trained in this intervention. Consequently, most patients receive sleep medication although evidence clearly indicate that CBT-I is more effective and should be the treatment of choice. In Norway 7% of the general population are prescribed hypnotics each year, with numbers likely to be higher in mental health care. As demand for CBT-I exceeds supply, a fully automated digital version of CBT-I (dCBT-I) has been developed that has been shown to be remarkably effective.

In this multicenter randomized controlled trial, we will test if this dCBT-I can be used to treat a large number of patients while they are still on the wait list to receive ordinary outpatient treatment in community mental health care clinics. Eight hundred patients will be randomized to dCBT-I or digital Patient Education about sleep (PE). The aims are to test if dCBT-I is effective in this patient group and if it can improve outcomes of ordinary treatment in mental health care and reduce medication use. Main outcomes will be assessed using patient self-report and official health registers. By focusing on improving sleep early in the course of treatment, using a digital treatment, the study represents a novel method of delivering mental health care services which could improve treatment quality and use of resources.

The candidate will be included in the Sleep and Circadian Rhythms Research group, lead by Håvard Kallestad, PhD, havard.kallestad@ntnu.no. The research group is integrated with the sleep clinic and acute ward at Østmarka, lead by Knut Langsrud. The research group has conducted several other randomized controlled clinical trials testing the effectiveness of interventions that act on sleep and the circadian system in individuals with mental disorders and in the general population. The candidate will participate in data collection of the above trial and will be able to write research papers from this or the other clinical trials that have been conducted in the research group.

Lifestyle factors and sex hormones as risk and causal factors for prostate cancer #

The incidence and mortality of prostate cancer in Norway are among the highest across the world. The known causes for the occurrence of prostate cancer are age and heredity that cannot be modified. The potential associations of lifestyle factors and sex hormones with overall and aggressive prostate cancer warrant further investigation, especially if they are the causal factors.

We will use the HUNT population data linking to the prostate cancer data from the Cancer Registry of Norway, including stage, metastasis and mortality. The population was followed up to 22 years. Longitudinal information on the lifestyle factors will be used. In addition, the Mendelian randomization (MR) method, using genetic variants as instruments for lifestyle or hormonal factors, will be applied to assess the potential causal associations. International data will be used to strengthen statistical power when appropriate.

 Identification of risk factors, particularly the underlying causal factors, will improve the effectiveness of prevention against prostate cancer. We are looking for a dedicated candidate who is keen on developing knowledge and skills in epidemiological methods and genetic epidemiology. You can find our scientific publications via https://www.ncbi.nlm.nih.gov/myncbi/xiao-mei.mai.1/bibliography/public/ Contact person: Xiao-Mei Mai, professor, Institutt for samfunnsmedisin og sykepleie 

Before the Beginning – Breaking the intergenerational cycle of cardiometabolic disease by preconception lifestyle interventions #

Maternal obesity and hyperglycaemia in pregnancy increase the long-term health risk for both mother and child, leading to an intergenerational cycle of cardiometabolic disease. Current lifestyle interventions typically start in the second trimester and have limited efficacy. Our hypothesis is that the pre-existing metabolic profile of future mothers needs to improve preconception to confer health benefits for mother and child. In this clinical project, we aim to discover how improving maternal preconception health will influence the cardiometabolic health of the mother during pregnancy and of the offspring. To reach these goals, we will determine the effects of two interventions: time-restricted eating and high intensity interval training, both of which rapidly improve glycaemic control. Time-restricted eating, in which food intake is confined to <10 h of the day without a deliberate reduction in energy intake, reduces adiposity and improves glycaemic control in animal models and in humans. High intensity interval training is time-efficient and enjoyable and involves short bursts of intense exercise separated by rest breaks. Our preliminary data shows that high intensity interval training is safe for the mother and foetus. In the first phase, women at risk of gestational diabetes who are planning a pregnancy will undergo these diet-exercise interventions, before and throughout pregnancy. In the second phase, we will identify underlying mechanisms for the effects of the interventions for mothers and babies. Our aim is to establish an optimal prevention strategy to improve maternal preconception and gestational health, therefore reducing the risk of cardiometabolic diseases in the future generations. This conceptual shift in maternal care provides a platform for improved health outcomes for mother and their children, breaking the intergenerational cycle of cardiometabolic disorders.

Forskerlinje-oppgave knyttet til dette prosjektet: Vi vil gjerne ha med oss en forskerlinjestudent på laget. Vi har flere problemstillinger som kan være relevante for en student. Studien vil innebære arbeid på lab, med ulike testmetoder, analyse av data, og klinikknær forskning. For mer informasjon, kontakt: trine.moholdt@ntnu.no, Forsker, Institutt for sirkulasjon og bildediagnostikk

Personalized cancer treatment by developing integrated MR methods and data analysis tools for functional and molecular assessment of tumors #

The MR Cancer group (http://www.ntnu.edu/isb/mr-cancer) studies functional and metabolic properties of cancer using both MR imaging and MR spectroscopic technologies. Our long-term objective is to improve and individualize cancer treatment by developing integrated MR methods and data analysis tools for functional and molecular assessment of tumors. We use a broad spectrum of systems for cancer studies, spanning from cultured cancer cells to humans, and have access to dedicated MR equipment for in vitro, ex vivo, preclinical and clinical research.

We have several large ongoing research projects supported by The Research council of Norway, the Norwegian Cancer Society and regional health authorities, and we can offer students tailored projects in line with their main interests.

For further information, please contact:Prof. Tone F. Bathen (95021097, tone.f.bathen@ntnu.no)

Identification of targets for intervention to prevent blinding eye disease in preterm born babies in Norway utilizing evolutionary computation models #

This assignment is part of an effort to search for targets for intervention to reduce the incidence of the blinding eye disease retinopathy of prematurity (ROP) among preterm born babies. ROP is prevalent especially among extremely preterm born babies, and incidence vary across and within countries. A set of risk factors and their relationships in the form of odds ratios have been identified, however we lack a tool to identify which children are at risk and which factors should be modified to prevent disease development.
This project will explore the use of evolutionary computation — potentially some form of genetic programming — to devise models that clarify relationships between a host of important variables used in predicting the occurrence of blinding ROP.

The student will have access to disease occurence and odds ratio data between parametres and outcomes obtained from 4500 patients from the Norwegian population and of 617 patients from the Extremely Low Gestational Age Newborns Study (ELGAN) in USA. Parametres and outcomes from each individual are: Presence of ROP; gestational age at birth (GA); birthweight (BW); ROP severity degree and ROP mode of treatment; Potential risk factors for developing ROP; small for gestational age (SGA) defined as birth weight below the 10th centile according to Norwegian growth charts, antenatal steroids (ANS) defined as any ANS before delivery, growth velocity at 36 weeks PMA (GV), surgically treated patent ductus arteriosus (PDA), medically treated PDA, necrotizing enterocolitis (NEC) defined as Bell’s stage 2 or 3, intraventricular haemorrhage grade 3-4 (severe IVH), and broncopulmonary dysplasia (BPD) defined as severe BPD with the need for at least 30% supplemental oxygen and/or ventilation support at 36 weeks; no. days with oxygen, ventilation, presence of sepsis; at which health care level the child was treated; no. days on parenteral nutrition (TPN).
Main tasks in this assignment are as following:
• Develop evolutionary computation models to identify targets for intervention to prevent ROP development solving problems such as: A new treatment is introduced that reduces the occurrence of the inflammatory condition of necrotizing enterocolitis (NEC). Assuming that the level of other parametres and odds ratios remain the same, what would be the resulting prevalence (percentage) of ROP?
• Validate the evolutionary computation model against existing population data from the Norwegian and North-American population
• Discuss the implementation, challenges and lay out future work

Supervisor: Dordi Austeng dordi.austeng@ntnu.no, associate professor and leader of the Norwegian Quality Register for ROP and researcher Tora Sund Morken, tora.s.morken@ntnu.no. External contacts: Olaf Dammann, visiting professor to NTNU and professor at Tufts University in Boston; Professor Keith Downing, Department of Computer Science, NTNU

Multimodal evaluering av kognitiv svikt hos Alzheimer pasienter #

Bakgrunn
Alzheimer´s sykdom (AD) rammer stadig flere mennesker globalt. I dag finnes det ca. 50 millioner mennesker med diagnosen AD i verden, et antall som beregnes å øke til 150 millioner innen 2050. Utfordringene for helsevesenet og samfunnet forventes derfor å øke markant.
Årsakene til AD er ennå ikke avklart og ingen effektiv behandling finnes i dag som kan stanse eller reversere sykdommen. Sannsynligvis finnes det undergrupper av pasienter med demens som til dels diagnostiseres under AD diagnosen. Dette utgjør et problem da rett klassifisering av demens er viktig for at man kan igangsette en pasient spesifikk behandling. Kan man identifisere biologiske markører som kan skille mellom undergrupper av AD pasienter har man kommet et stykke på vei i klassifiseringen. Det vil også hjelpe oss til bedre å forstå patologien som forårsaker sykdommen.
Elektroencefalogram (EEG) er en måte å registrere hjerneaktivitet på. Da hjerneaktiviteten endres allerede ganske tidlig ved AD, vil EEG være en mulig måte å sub-gruppere AD pasienter på og hjelpe til å sikre en diagnose så tidlig i sykdomsforløpet som mulig, slik at behandling kan startes raskt.

Mål
Målet med prosjektet er å bruke EEG til å identifisere markører for Alzheimer´s sykdom i et tidlig stadium, og følge sykdomsutviklingen over tid.

Metoder
Pasienter med lette kognitive problem vil inkluderes i studien og sammenlignes med AD pasienter i forskjellige stadier av sykdommen. Pasientene vil testes med nevropsykologiske tester, minimal mental status examination (MMSE) og Montreal Cognitive Assessment (MOCA). Magnetkamera avbildning av pasientene vil gjøres og pasientenes hjerneaktivitet vil registreres med EEG.

Arbeidsoppgaver
Hjelpe med EEG registering av pasienter og teste pasientenes kognitive funksjoner med enklere kognitive tester. Koordinere og ha ansvar for datainnsamling, strukturere data og gjennomføre data analyser. Jobbe i tverrfaglige team og tilrettelegge logistikk.

Resultat
Resultatene fra prosjektet forventes å kunne resultere i 1-2 artikler. Videre er det mulig å søke om å fortsette prosjektet mot en PhD etter at medisinerstudiet er ferdig.

Kontaktpersoner
Kontaktpersoner: Axel Sandvig axel.sandvig@ntnu.no, Institutt for Nevromedisin og bevegelsesvitenskap, NTNU. Ingvild Saltvedt ingvild.saltvedt@ntnu.no Institutt for Nevromedisin og bevegelsesvitenskap og Avdeling for geriatri, St.Olavs hospital

Rehabilitation of stroke patients #

Background
Stroke care requires more bed days in hospitals and rehabilitation facilities than most other somatic illnesses. This problem is set to increase significantly with an aging population. It is therefore a growing need to improve stroke rehabilitation that aims to improve functional neurological outcome after stroke.

Aims
This project aims to develop patient-specific stroke rehabilitation based on a detailed multiparametric assessment of the functional neural network after the brain damage. This assessment will be used to design a personalized rehabilitation program in which the patients will train restoration of motor functions while both muscle and brain activities are registered and quantified with electroencephalogram and electromyography.

Methods
Different magnetic resonance imaging (MRI) protocols will assess the degree of brain damage and quantify the surviving functional brain tissue. Patient-specific rehabilitation will use this knowledge to train motor-function. EEG, EMG, and degree of improvement in movement will be quantified using advanced 3-dimensional kinematic video analysis.

Tasks
• Assist in the reqruitment of patients in close collaboration with the stroke unit, St Olavs hospital
• Documentation of degree of brain damage correlated with neurological assessments of motorfunction
• Use EEG, EMG and kinematic video equipment during training of motor functions.
• Analysis of data

Results
We aim to publish 1-2 articles based on results from the project. Furthermore, it will be possible to extend the project towards a PhD after completion of the medical studies.

Who to contact Axel Sandvig; axel.sandvig@ntnu.no, Institute for Neuromedicine and movement science, NTNU. Hanne Ellekjær; Hanne.Ellekjer@stolav.no; Institute for Neuromedicine and movement science NTNU and Stroke Unit, St.Olavs hospital

Post-stroke epilepsy #

Background
Post-stroke epilepsy increases morbidity and mortality in stroke patients. Due to heterogeneity in study designs, the rates of early post-stroke epilepsy are estimated between 2% to 33% while late seizure rates are reported in the range of 3% to 67% in various studies. Stroke accounts for 30% of newly diagnosed seizures in patients >60 years old. Since post-stroke seizures negatively impact on patient recovery after stroke further studies are needed to assess the impact of post-stroke seizures and correlate those with biological markers to predict those who may be at particular risk.

Main Aims
• Document incidence and prevalence rates of post-stroke seizures in stroke patients admitted to the stroke unit St Olavs hospital
• Classify types of post-stroke seizures
• Document rates of early (< 2 weeks post-stroke) versus late (> 2 weeks post-stroke) seizures
• Correlate post-stroke seizures with degree of brain damage (MRI, biological markers)
• Correlate seizure rates with neurologic dysfunction
• Evaluate the effect of type of anti-epileptic medication on seizure frequency
• Correlate data with electroencephalogram (EEG) assessments of seizures when available.
• In a prospective study, register brain activity in stroke patients admitted to the stroke unit and repeat the EEG registration at 3 time-points following the patients one year after the stroke

Methods
• The study is a retrospective cohort investigation of stroke patients admitted to the stroke unit, St Olavs hospital.
• Patient journals at the stroke unit, St Olavs hospital will be assessed.
• Based on CT and MR images, estimate degree of stroke induced brain damage.
• Document types of anti-epileptic medication and effect on seizure frequency.
• Classify seizure types recorded with EEG registration of brain activity.

Main Tasks include
1. Document incidence and prevalence rates of post-stroke seizures in a cohort of stroke patients admitted to the stroke unit St Olavs hospital.
2. Correlate frequency and types of post-stroke seizures with degree of brain damage estimated using CT and MRI with assessments of neurological function documented in the patient journals.
3. Evaluate EEG registrations of post-stroke seizures to document types of seizures with stroke frequency and degree of brain damage
4. Evaluate effect of seizure control with types of anti-epileptic medication and dosages
Results
We aim to publish 1-2 articles based on results from the project. Furthermore, it will be possible to extend the project towards a PhD after completion of the medical studies.

Who to contact
Axel Sandvig; axel.sandvig@ntnu.no; Institute of Neuromedicine and movement science; NTNU, Morten Engstrøm; morten.engstrom@ntnu.no; Institute of Neuromedicine and movement science; NTNU and department of Clinical Neurophysiology, St Olavs Hospital. Hanne Ellekjær; Hanne.Ellekjer@stolav.no; Institute of Neuromedicine and movement science; NTNU and Stroke unit, St Olavs Hospital.

Placental and fetal cerebral blood flow related to maternal androgens, insulin resistance and inflammation in women with PCOS #

Do you want to investigate fetal brain circulation when the mother has PCOS? Well, then this is the project for you.

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women, with a prevalence of 10-18% in the general population. We know that women with PCOS have more miscarriage, preterm delivery, gestational diabetes and preeclampsia - all serious pregnancy complications. Maternal PCOS status also seems to affect both the somatic and psychologic health of the offspring. Both daughters and sons of PCOS women have increased risk to develop overweight/obesity, central adiposity, increased insulin resistance, and inferior blood lipid profile. Metformin, an insulin-resistance lowering drug, commonly used to treat type 2 diabetes is a drug that frequently has been used in women with PCOS both before and during pregnancy.

 Three randomized controlled trails have been conducted at NTNU/ St Olav hospital with the aim to learn more about the effects PCOS and a possible treatment with metformin have on the pregnancy and the offspring. Some questions have been answered but not all, we want to know more, and are going to use data from these trials to get more knowledge. We don’t know how PCOS and metformin influences the blood flow though the placenta and the fetal brain.

Why is this important to find out?

The blood flow though the placenta and fetal brain are both indicators for fetal wellbeing and fetal. Both these factors can influence the baby for the rest of its life. We want to use Doppler measurements from the three randomized controlled trails to explore placental blood flow and fetal brain circulation in relation to central features of PCOS, i.e. hyperandrogenemia, insulin resistance and inflammation. Also, placental hormones will be related to placental circulation. This study will be based on decade-long, extensive, goal-oriented collection of biologic material and data, in cross-disciplinary cooperation with leading researchers in fetal medicine, ultrasonography, physiology and inflammation. The research group  “Women’s health and PCOS” at IKOM/NTNU is responsible for this project and we have a broad collaboration both local, national and international colleagues.

 If you think that this might be an interesting project, please get in touch with us for more information.

Contact: Birgitte Kahrs birgitte.h.khars@ntnu.no and Eszter Vanky eszter.vanky@ntnu.no

**HUNT og utvikling i bruk av alternativ behandling** #

En relativt stor andel av befolkningen bruker alternativ behandling som akupunktur, homeopati mm. Det gjør det viktig å ha kunnskap om denne gruppen. HUNT har hatt med et eget spørreskjema i både HUNT 3 og 4, samt hatt spørsmål om alternativ behandling i de andre undersøkelsene. Dette er et unikt datamateriale i verdenssammenheng for å studere utvikling i bruk av alternativ medisin over lang tid. Innenfor dette overordnede tema er det mulig å velge ut ulike problemstillinger, for eksempel å se på bestemte pasientgrupper, sammenligning med annen helsetjenestebruk og koble på registerdata om sykelighet og dødelighet for å sammenligne utkomme mellom de som bruker alternativ behandling og de som ikke har gjort det.

Dette prosjektet vil være innenfor forskningsgruppen for helsetjenesteforskning ved Institutt for Samfunnsmedisin og Sykepleie (ISM). Veileder vil være Aslak Steinsbekk, Professor i Medisinske atferdsfag og Helsetjenesteforskning og Professor II ved Nasjonalt senter for e-helseforskning, Tlf: 73 59 75 74, E-post: aslak.steinsbekk@ntnu.no

**Digital samhandling om personer med store og sammensatte behov.** #

Personer med komplekse behov er den gruppen pasienter/brukere som alle tjenestene er i kontakt med, men som ingen av tjenestene kan ta ansvar for alene. Det er personer som på grunn av helsemessige eller sosiale forhold har behov for hjelp fra flere spesialiserte tjenester og som har begrensede forutsetninger for å ivareta egne behov. Dette er også de personen som har størst behov for helsetjenestens ressurser, og de finnes blant de 5% som har behov for 50% av ressursene målt i forbruk. Disse pasientene blir ikke «friske». Målet er å holde de på høyest mulig mestrings og funksjonsnivå over tid.

I forskningsprosjektet «DignityCare» skal det studeres hva som gjøres for å gi helhetlige og koordinerte tjenester til personer med komplekse behov i arbeidet med å realisere «En innbygger - En journal». Det skal gjøres ved bl.a. å følge og sammenligne arbeidet i Helseplattformen i Helse-Midt-Norge og hvordan den nasjonale arbeidet gjøres i Helse Nord, samt utvikle en digital løsning for samhandling innenfor disse områdene. Forskerne vil følge prosessene og fortløpende gi innspill underveis om det man finner (aksjonsforskning). Forskernes hypotese er at personer med komplekse behov er de som vil ha størst nytte av et helhetlig digital samhandling på tvers av tjenestene. Ved å lage løsninger som fungerer for disse, vil man lage løsninger som bidrar til bedre samhandling og koordinering også for andre, inkludert bedre tjenester og ressursutnyttelse.

I DignityCare prosjektet er det mulighet for ulike prosjekt for en forskerlinjestudent med interesse for e-helse og samhandling.

Dette prosjektet vil være innenfor forskningsgruppen for helsetjenesteforskning ved Institutt for Samfunnsmedisin og Sykepleie (ISM). Veileder vil være Aslak Steinsbekk, Professor i Medisinske atferdsfag og Helsetjenesteforskning og Professor II ved Nasjonalt senter for e-helseforskning, Tlf: 73 59 75 74, E-post: aslak.steinsbekk@ntnu.no

**The effects of aerobic interval training on lipoprotein subfractions in overweight adolescents** #

The aim of the study is to compare the effects of a multidisciplinary approach (MTG) and aerobic interval training (AIT) on lipoprotein subfractions in overweight adolescents. 54 overweight and obese adolescents (age, 14.0+−0.3 years) were referred to medical treatment at St Olav’s Hospital, Trondheim, Norway. The adolescents were randomized to either AIT (4×4 min intervals at 90% of maximal heart rate, twice a week for 3 months) or to MTG (exercise, dietary and psychological advice, twice a month for 12 months). Blood samples were collected before and after the intervention period. VO2max (maximal oxygen uptake) and endothelial function were superior in the AIT group versus the MTG group after the intervention. BMI (body mass index), percentage of fat, MAP (mean arterial blood pressure), glucose and insulin regulation were also significantly improved in the AIT group compered to the MTG group. To further explore the beneficial effects of AIT and MTG on cardiovascular health in these individuals, we will now apply NMR lipidomics technology to determine whatever changes occur on the lipoprotein subfraction level although no changes in standard lipids were shown. Lipidomics is a recently developed research area that apply different techniques to perform large-scale analyses of circulating lipids. One of the main methods for lipidomics analysis is based on Nuclear Magnetic Resonance (NMR). NMR lipidomics utilizes differences in lipoprotein composition, size and density to extract information on lipoprotein subclasses. Several studies have demonstrated an association between lipoprotein subfractions and future cardiovascular health. This suggest that more refined analyses of lipoprotein subfractions may lead to further improvements in cardiovascular disease prevention and perhaps even to the identification of appropriate targets for therapeutic intervention in individual patients. Lipidomics technology has developed rapidly over the past decade, to the point where clinical application now is possible.

Resultatene fra dette prosjektet kan ende opp med 1-2 artikler, samt at vi har samlet blodprøver fra et liknende treningsprosjekt som kan utgjøre materiale for en potensiell artikkel 3 i de tilfeller hvor man ønsker å fullføre en PhD på et senere tidspunkt. Det kan også være aktuelt på et senere tidspunkt å inkludere en studie fra Helseundersøkelsen i Trøndelag på beslektet problemstilling som potensiell artikkel 3 i en avhandling.

Kontaktinfo: Anja Bye, anja.bye@ntnu.no, Senior Researcher, Cardiac Exercise Research Group (CERG), Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway, https://www.ntnu.edu/cerg

Informasjon #

For å få vite mer om forskerlinjestudiet og hvordan finne prosjekt/veileder, ta kontakt med faglig leder for forskerlinjen, professor Anna Bofin, eller Cicilie Nordvik ==

Vi anbefaler også å ta kontakt med forskerlinjestudentene selv gjennom studentenes egen linjeforening, Signifikant.

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