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We have still not found a textbook suitable for this course, and have therefore continued using selected scientific papers as course material/curriculum. We changed the content of the course in 2023 to focu more on bacterial genomics, and changed the topic of the compulsory written assignment from a literature review to a bioinformatics exercise report, which must be approved before the student could take the written exam. Written exam counted 100 % of the final grade.

The lectures were generally well received by the students, while some stduents struggles to som eextent with the bioinformatics exercise. To help the studenys the bioinformatician gave detailed feedback to each student on their preliminary report and this led to cosiderable improvement of the final reports.We hd a Q&amp;A meeting after all lectures were finised, and som efew stduents showed up, but there were not som many questions. Students´ achievements of learnbing outcomes could have been better, and the final grades were lower that previous years. Based on the students performance at the written exam it is not obvious that there were spesific topics that led to this lower grades.

We will continue the search for a seach for a suitable textbook. We will evaluate and adjust how we introduce and supervice the bioinformatics exercise in the course. We will also consider to introduce more student activating activities in the course, as well as discussion forum for the students.

NTNU:TIA:REST

Institutt for klinisk og molekylær medisin

Department of Clinical and Molecular Medicine

Ingen trykte eller håndskrevne hjelpemidler tillatt. Bestemt, enkel kalkulator tillatt.

Engelsk

Mer om vurdering

Retake of exam: If the compulsory bioinformatics exercise has been approved in a previous semester, it is sufficient to retake the written exam. If the bioinformatics excercise is not passed, the excercise must be resubmitted and approved before the written exam can be re-taken. Students with legitimate leave of absence at the final examination and students who receive the grade F make re-sit the examination in the following semester.The language of instruction is English. The compulsory bioinformatics exercise and the written exam must be answered in English.

Anbefalte forkunnskaper

Basic knowledge in microbiology, cell biology, biochemistry, and molecular biology.

Faglig innhold

In this course you will study the molecular biology of bacteria which cause infection in humans. We will focus on selected infectious diseases causing both sporadic infections and outbreaks, and the bacteria which cause these diseases. You will study the clinical presentation of the disease and its epidemiology, the genomic structure of the microorganisms, mobile genetic elements and the mechanisms of horizontal gene transfer, virulence factors and how the microorganisms cause disease, and antimicrobial resistance. Further, you will learn about molecular methods for diagnosis and genotyping of bacteria. You will also get experience with basic bioinformatics methods for analysis and comparison of bacterial nucleic acid and genome sequences. Finally, you will study the relation between the human microbiome and health/disease and basic methagenomics methods for microbiome analyses.

Kursmateriell

Læringsutbytte

After completion of the course the student should be able to demonstrate a strong general knowledge in molecular medical microbiology:<ul><li>have good knowledge about the molecular biology of bacteria including mobile genomic elements</li><li>have good knowledge about selected bacterial infections and their epidemiology</li><li>have good knowledge about molecular methods for diagnosis of bacterial infections</li><li>have good knowledge about molecular methods for genotyping of bacteria, and their use in the investigation of bacterial infectious diseases</li><li>have basic knowledge about bioinformatics methods and be able to perform analyses and comparison of bacterial nucleotide and genome sequences</li><li>have basic knowledge about the human microbiome and metagenomics methods for microbiome analyses</li></ul>

Læringsformer og aktiviteter

Lectures, a compulsory bioinformatics exercise which must be approved before the student can take the written exam. Written exam count 100 % of the final grade.

Oppgave

Molekylær medisinsk bakteriologi

Molekylærmedisin

Biokjemi

Biologi

Cellebiologi

Medisin

Molecular Medicine (Master's Programme)

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The course leader will review the information about the compulsory written assignment. Arrange a Q&A session early in the course on how to choose topic for the written assignment and how to do limit/write the paper.

Tiltak

Compulsory written assignment

The cours leader will search for a book covering the content of the course, and if we find one use this as syllabus instead of the scientific papers. If we do not find a relevant book, we continue using an updated list of scientific papers.

Course syllabus

Action plan from course report MOL3023 Autumn 2020:<ul><li>The course was carried out according to plan, except that the papers on the curriculum were not put on Blackboard until course coordinator was asked by the students. I will ensure this does not happen next year by applying a checklist for task that need to de done.</li><li>It was difficult to find an external sensor, probably due to the considerable workload of accessing literature reviews.</li><li>Due to an administrative error the written exam consisted of only ten questions. The student in the reference group found she did not need 4 hours for that finishing the exam, and that many student left the exam room early. So, next year we will either expand each question or increase the number of questions to 15. </li></ul> Evaluation MOL3023 Autumn 2021: The content in Blackboard was set up before start of the course in sepyember 2021. External sensor was recruited in good time this year. We ensuerd that all planned exam questions were included in the written exam.

Comments from the student reference group:Lectures:academic content of the teaching which was not too low or too high. They commented that the lectures generally had a high quality and were well presented. The students liked the that lectures wer taught both as physical and hybrid lectures, and would prefer that lectures were recorded, esp. since there is no spesific book detailing the curriculum of the course. Compulsory written assignment: the students would like more information on how to write the assignment and they would like a session wher the students couls ask questions about the written assignment. Such a session was arranged, but few students met. The students would like more information whether they had to select one of the topics listed or if they could choose a sub-topic within ine of the fields listed. The students would like more help on how to limit the content of the assignment. Syllabus: the students found the volume of literature OK. Some students found it difficult to determine what topics within the syllabus that was most relevant for the exam. Exam: the students would like to have more previous exam quenstions for excercise before the written exam.

Comments from course leader:The students in the reference group seemed generally satisfied with the content of the course, allthough they had minor comments as listed above.

Alle trykte og håndskrevne hjelpemidler tillatt. Alle kalkulatorer tillatt.

Basic knowledge in microbiology, cell biology, biochemistry, and molecular biology

Retake of exam: If the assignment is passed in a previous semester, it is sufficient to retake the written exam. If the assignment is not passed, both the assignment and the written exam must be re-taken.The language of instruction is English, and the exam must be answered in English.

In this course you will study the molecular biology of microorganisms such as bacteria and viruses which cause infection in humans. We will focus on selected infectious diseases causing both sporadic infections and outbreaks, and the microorganisms, which cause these diseases. You will study the clinical presentation of the disease and its epidemiology, the genome structure of the microorganisms, the mechanisms of horizontal gene transfer, virulence factors and how the microorganisms cause disease, and antimicrobial resistance. Further, you will learn about molecular methods for diagnosis and genotyping of microorganisms. You will also get experience with basic bioinformatics methods for analysis and comparison of nucleic acid sequences, both nucleotide and genome sequences.  

Lectures, a bioinformatics exercise and a compulsory written assignment. Written exam and the compulsory written assignment count 50 % of the final grade each.

After completion of the course the student should be able to demonstrate a strong general knowledge in molecular medical microbiology: <ul><li>have good knowledge about the molecular biology of microorgansims </li><li>have good knowledge about selected infectious diseases and their epidemiology </li><li>have good knowledge about molecular methods for identification and quantification of microorganisms </li><li>have good knowledge about molecular methods for genotyping of infectious agents, and their use in the investigation of infectious diseases </li><li>have basic knowledge about bioinformatics methods and be able to perform analyses and comparison of microbial nucleotide and genome sequences.</li></ul>

Molekylær medisinsk mikrobiologi med essay

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This autumn three students were appointed to the reference group. We had three meetings, were all three students participated in the first meeting, two in the second and only one in the last meeting.The students did not get much input from other students in the course, and had few comments. They commented, as follows: "We found the lectures well organized with interesting material. I think the complexity level is about where it should be considering different backgrounds. The bioinformatics exercise is easy to follow, and instructions are clear." The students also commented that they would like to have all lectures recorded, and they would have liked laboratory exercises as well.

Er læringsutbyttet oppdatert og relevant? The learning objectives were updated last year, and should be in accordance with the teaching in the course. Hvordan er læringsutbyttet  kommunisert til studentene? Through emnekatalogen, in blackboard and in the first lecture. Er det god sammenheng mellom emnets læringsutbytte og parallelle og tidligere emners læringsutbytte?​ Yes, except that the compulsory written assignment was close to the assignment in the compulsory course MOL3100, for these students who chose infection as topic in that course. Next year I will inform the students that they have to choose different topics for their assignments in these two courses.

Hvordan bidrar læringsaktivitetene til at studentene oppnår læringsutbyttet for emnet (nivå, progresjon, relevans)?  The learning activities consists of lectures, reading of selected scientific papers, bioinformatics exercise and a compulsory written assignment. All these combined are highly relevant to gain the learning outcome. Hvordan er studentenes egeninnsats og motivasjon?  This is difficult to assess, since all teaching was done through video conference. Hvordan er læringsmiljøet? ​​This year all teaching was through video conference which makes it difficult to access the learning environment.

This year the exam was done as 4 hour home exam, and the questions were mainly of a type where the students had to combine knowledge to answer.

Retake of exam: If the assignment is passed in a previous semester, it is sufficient to retake the written exam. If the assignment is not passed, both the assignment and the written exam must be re-taken.


The language of instruction is English, and the exam must be answered in English. 


Lectures, a bioinformatics exercise  and a compulsory written assignment.  Written exam and the compulsory written assignment count 50% of the final grade each.



After completion of the course the student should be able to demonstrate a strong general knowledge in molecular medical microbiology: 
	have good knowledge about the molecular biology of microorgansims 
	have good knowledge about selected infectious diseases and their epidemiology 
	have good knowledge about molecular methods for identification and quantification of microorganisms 
	have good knowledge about molecular methods for genotyping of microorganism agents, and their use in the investigation of infectious diseases
	have basic knowledge about bioinformatics methods and be able to perform for analyses and  comparison microbial nucleotide and genome sequences.


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Molekylær medisinsk bakteriologi - MOL3023